With the passage of time, significant advances have been made in the process of pelletization due to the incorporation of specialized techniques for their development. Extrusion-spheronization seems to be the most promising process for the optimum delivery of many potent drugs having high systemic toxicity. Small free flowing spherical units ranging in size, prepared by agglomeration of fine powders called pellets. • Their size and shape allow their administration as injections and also for oral drug delivery. • Pellets range in size, typically, between 0.5 – 1.5 mm, though other sizes could be prepared. 3. The petrochemical secondary effluent (PSE) is typical refractory wastewater derived from the petrochemical industries, which requires advanced treatment due to the strict environmental protection policies. Catalytic ozonation is one of the most widely used advanced oxidation technologies in wastewater treatment because of its high mineralization rate, in which the alumina-based catalyst Pelletization is an agglomeration process that converts fine powders or granules of bulk drugs and excipients into small, free flowing, spherical or semi-spherical units, referred to as pellets. This review outlines manufacturing of spherical pellets. The manufacturing techniques include Drug layering, involving dry mixing, wet granulation, extrusion, spheronization, drying, and screening. The first step is dry mixing of the drug and excipients in suitable mixers followed by wet granulation, in which the powder is converted into a plastic mass that, can be easily extruded. The wet mass is extruded through cylindrical dies or Pelletizers are equipped with blades to cut the pellets in desired size (Chen et al., 2008 ). Lignin present in the biomass has the ability to bind the fibers ( Kalish, 2012 ). Temperature of the pellets leaving pelletizer is in between 80 and 90°C; thus, cooling becomes a very important process for the pelleting. Fig. 5. The destructive nucleation growth mechanism of high-shear pelletisation. The proposed mechanism is not a step-wise process, but a combination of all different sub-mechanisms which occur at the same time. During liquid addition, the formation of primary and secondary nuclei is the major mechanism. Every technique has their own advantages and limitations, therefore a thorough understanding of the process variables is important before choosing a pelletization method. In the pharmaceutical industry , pellets can be defined a s small, free - flowing, spherical particulates manufactured by the agglomeration of fine powders or granules of drug substances and excipients using appropriate Also, a new vision about the future development of the pelletization process is introduced. 2. Pellets production. Pelletization, briquetting, extrusion, and tumble are the different types of biomass densification [66]. Pelleting can be performed either by using a uniaxial piston-cylinder unit to produce single pellets or a pellet mill that 2. DEFINITION:- Extrusion is a Process in which pharmaceutical material or other material is forced through a series of dies to create desired shapes. Spheronization or maramuerization, is a rapid and flexible process where pharmaceutical products are made into small spheres, or spheroids of diameter ranging from about 0.5mm to 10mm. 2. MWJA.